Wednesday Night has one of the best lineups of College Basketball season. The sports bookies will open all sorts of bets for this night. First, the Big 12 will see Kansas trying to extend their Conference domination on ESPN.

Duke and Syracuse will go in an ACC battle. The Blue Devils are favorites, but home-court will give the Orange more than just a puncher’s chance. Don’t sleep on the home team.

Louisville and North Carolina will give is the best matchup of the night. Both teams are trending up and currently inside the Top Ten. This game should be dramatic and decided in the last seconds.

And last we get to see Villanova hosting Butler in a Big East clash. This game will close the night on Fox Sports 1.

These are the Wednesday College Basketball Winners:

TCU Horned Frogs (17-10) at (3) Kansas Jayhawks (24-3

• When: Wednesday, February 22, 2017
• Game Time: 7:00 PM ET
• Where: Allen Fieldhouse, in Lawrence, Kansas
• TV Info: ESPN 2

Kansas has dominated the Big 12 over the last decade, but they don’t take it for granted. The Jayhawks have won six of the lasts seven games, including two dramatic wins over the last week. The sports betting agent will make Kansas the favorite from now on. They have talented. They showed heart in the comeback win over West Virginia. And they didn’t panic against Baylor.

The Jayhawks beat TCU this season with an 86-80 when the game was played at the Horned Frogs facilities. It’s not going be that close at the Allen Fieldhouse. TCU has lost three straight, including defeats against Baylor, Oklahoma State, and Iowa State.

Their offensive pace is good enough to complicate most teams in College Basketball, but not Kansas. TCU averages 74.5 points per game against 82.1 from the Jayhawks.

The Jayhawks are 34-16-2 ATS in their last 52 Wednesday games. But they haven’t been able to beat the per head sportsbooks in the last few games. They are 0-5 ATS in their last 5 games as a home favorite, 0-5 ATS in their last 5 home games and 0-4 ATS in their last 4 home games vs. a team with a losing road record.

TCU hasn’t been impressive either. The Horned Frogs are 1-5 ATS in their last 6 games following a straight up loss, 1-4 ATS in their last 5 road games and 0-4 ATS in their last 4 games overall.

College Basketball Picks: Kansas by ten.

 (10) Duke Blue Devils (22-5) at Syracuse Orange (16-12)

• When: Wednesday, February 22, 2017
• Game Time: 7:00 PM ET
• Where: Carrier Dome, in Syracuse, New York
• TV Info: ESPN

At any other moment, Duke against Syracuse would be an instant classic in the ACC. This year the Orange has stumbled around and hasn’t looked like a basketball powerhouse.

Syracuse has lost their last three games in a row, including defeats against Pittsburgh, Louisville, and Georgia Tech. One can understand the loss against the Cardinals, but their effort against the Yellow Jackets was embarrassing. The Orange averages 76.1 points per game, but they allow 70.1 points each night. The pph sportsbooks don’t buy Syracuse because their zone defense is struggling this season. Many teams have found ways to penetrate it.

Duke is on a seven-game winning streak that includes impressive wins over the Notre Dame, Clemson, and Virginia. The Blue Devils can evolve and play the game is in front of them to get the win. Either a high scoring affair like they had against the Tar Heels or a low scoring matchup like the one they had against the Cavaliers.

Expect Syracuse to give a battle early, but in the end, the away team should take a commanding lead and manage the rest of the game. The Blue Devils are 3-8-1 ATS in their last 12 road games and 5-11 ATS in their last 16 games overall.

The Orange is 7-1 ATS in their last 8 home games, 4-1 ATS in their last 5 games as a home underdog and 4-1 ATS in their last 5 games vs. a team with a winning % above .600.

College Basketball Predictions: Take Duke to win but Syracuse to cover the spread.

 (7) Louisville Cardinals (22-5) at (8) North Carolina Tar Heels (23-5)

• When: Wednesday, February 22, 2017
• Game Time: 9:00 PM ET
• Where: Dean E. Smith Center, in Chapel Hill, North Carolina
• TV Info: ESPN

Louisville against North Carolina is one of the best game of the week. Both teams are inside the top-10 and on tremendous winning streaks.

The Cardinals have won six of their last seven outings, including three wins in a row over Miami, Syracuse and Virginia Tech. They score 77.8 points per game and allow 64.1 points. Their 13-point differential is a great one to beat most teams in the College Basketball landscape.

The Cardinals are 6-1 ATS in their last 7 games following an ATS loss, according to the NCAAB betting trends. They are 4-1-1 ATS in their last 6 road games, 5-2-1 ATS in their last 8 games following a straight up win.

The problem for Louisville is they are about to face a squad that can match them in intensity and can score just as many points every time they jump on the floor. The pay per head sportsbooks understand North Carolina averages 86.9 points per game; it is the sixth-best mark in the nation.

In 11 of their last 15 games, the Tar Heels has scored over 80-points per game. In seven of those, they scored over 90-points and got different wins. Keep in mind The Tar Heels are 19-7 ATS in their last 26 home games, 4-1 ATS in their last 5 home games vs. a team with a winning road record and 8-3 ATS in their last 11 home games vs. a team with a road winning % of greater than .600.

NCAAB Picks: North Carolina to win and cover the spread.

 (22) Butler Bulldogs (21-6) at (2) Villanova Wildcats (26-2)

• When: Wednesday, February 22, 2017
• Game Time: 9:00 PM ET
• Where: The Pavilion, Villanova, Pennsylvania
• TV Info: FS1

The Big East will have a huge game on Wednesday Night. The Champs, Villanova Wildcats, will host the Butler Bulldogs in a meeting of two teams that will aim for the Conference championship.

Butler has won three of their last four games, but they need a better effort to beat Nova. The Wildcats are ranked as the second-best team in the country. They have experience and are just waiting to get into their tournament to hit the full gear.

The Wildcats are 2-6 ATS in their last 8 games following a straight up win and 8-3 ATS in their last 11 games as a favorite of 0.5-6.5 points.

NCAAB Predictions: Villanova.